What is P-Glycoprotein?

You may have heard of p-glycoprotein as an "efflux membrane transporter" or a "multidrug resistance pump."

If you looked at those words and then thought, "yes, but what is it?" then you're in luck.

I've made a quick video covering the basics here.

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Want more detail? Check here.

Amin M. L. (2013). P-glycoprotein Inhibition for Optimal Drug Delivery. Drug target insights, 7, 27–34. doi:10.4137/DTI.S12519
Cario E. (2017). P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers. World journal of gastroenterology, 23(9), 1513–1520. doi:10.3748/wjg.v23.i9.1513
Hano, M., Tomášová, L., Šereš, M., Pavlíková, L., Breier, A., & Sulová, Z. (2018). Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors. Molecules (Basel, Switzerland), 23(2), 337. doi:10.3390/molecules23020337

Thanks for sharing!

Camille Freeman

Hi there. I'm the hippie who started Physiology for Hippies. I'm an associate professor at MUIH, where I teach physiology to students in the herbal medicine, nutrition and yoga therapy programs. I have two small children, an overgrown garden + an endless appreciation for the human body.